Interactions of DNA with graphene and sensing applications of graphene field-effect transistor devices: A review

Graphene field-effect transistors (GFET) have emerged as powerful detection platforms enabled by the advent of chemical vapor deposition (CVD) production of the unique atomically thin 2D material on a large scale. DNA aptamers, short target-specific oligonucleotides, are excellent sensor moieties for GFETs due to their strong affinity to graphene, relatively short chain-length, selectivity, and a high degree of analyte variability. However, the interaction between DNA and graphene is not fully understood, leading to questions about the structure of surface-bound DNA, including the morphology of DNA nanostructures and the nature of the electronic response seen from analyte binding. This review critically evaluates recent insights into the nature of the DNA graphene interaction and its affect on sensor viability for DNA, small molecules, and proteins with respect to previously established sensing methods. We first discuss the sorption of DNA to graphene to introduce the interactions and forces acting in DNA based GFET devices and how these forces can potentially affect the performance of increasingly popular DNA aptamers and even future DNA nanostructures as sensor substrates. Next, we discuss the novel use of GFETs to detect DNA and the underlying electronic phenomena that are typically used as benchmarks for characterizing the analyte response of these devices. Finally, we address the use of DNA aptamers to increase the selectivity of GFET sensors for small molecules and proteins and compare them with other, state of the art, detection methods.     

Molecularly engineered graphene surfaces for sensing applications: A review

Graphene is scientifically and commercially important because of its unique molecular structure which is monoatomic in thickness, rigorously two-dimensional and highly conjugated. Consequently, graphene exhibits exceptional electrical, optical, thermal and mechanical properties. Herein, we critically discuss the surface modification of graphene, the specific advantages that graphene-based materials can provide over other materials in sensor research and their related chemical and electrochemical properties. Furthermore, we describe the latest developments in the use of these materials for sensing technology, including chemical sensors and biosensors and their applications in security, environmental safety and diseases detection and diagnosis.     

Momentum transfer effects in near surface electron energy loss

We examine two formulations for the differential surface excitation parameter (DSEP): one provided by Tung et al. and the other given by the Chen–Kwei position‐dependent differential inverse inelastic mean free path integrated over the electron trajectory. We demonstrate that the latter converges to the former provided that the dielectric function of the solid does not depend on the momentum transfer or it depends on just the momentum transfer component parallel to the surface. Tung's DSEP represents therefore an approximation to the Chen–Kwei DSEP calculated for a dielectric function with no restrictions on the momentum dependence. The approximation is shown to work in the limit of small momentum transfer and to imply an error of 4%–5% for electrons traveling through the solid with energy E = 1 keV. Copyright © 2015 John Wiley & Sons, Ltd.     

扩散方程单内点精细积分法与差分法比较研究

一维扩散方程初值问题可以用全域或子域精细积分求解。子域积分可以采用不同数量的内点，单内点是其最简单的情况。当单内点精细积分中的传递函数即指数函数用其泰勒展开式的一阶近似来替代时，精细积分转化为差分方程。本文研究了这一对应关系。各种常见差分格式均找到了对应的单点精细积分格式，并在单点精细积分一般公式中得到了统一表达形式     

Correct Solutions of Plane Elastic Problems for a Half-Plane

Continuous and integrable solutions and one-to-one relationships between boundary forces and displacements are found through the direct integration of the differential equations of the plane elastic problem for a half-plane with boundary conditions for either forces or displacements or with mixed boundary conditions. The necessary equilibrium conditions for forces and the compatibility conditions for displacements that ensure the correctness of the solutions are formulated     

End Effects in Anti-plane Shear for an Inhomogeneous Isotropic Linearly Elastic Semi-infinite Strip

The purpose of this research is to further investigate the effects of material inhomogeneity on the decay of Saint-Venant end effects in linear isotropic elasticity. This is carried out within the context of anti-plane shear deformations of an inhomogeneous isotropic elastic solid. The mathematical issues involve the effects of spatial inhomogeneity on the decay rates of solutions to Dirichlet or Neumann boundary-value problems for a second-order linear elliptic partial differential equation with variable coefficients on a semi-infinite strip. In previous work [1], the elastic coefficients were assumed to be smooth functions of the transverse coordinate so that the material was inhomogeneous in the lateral direction only. Here we develop a new technique, based on a change of variable, to study generally inhomogeneous isotropic materials. The governing partial differential equation is transformed to a Helmholtz equation with a variable coefficient, which facilitates analysis of the influence of material inhomogeneity on the diffusion of end effects. For certain classes of inhomogeneous materials, an explicit optimal decay estimate is established. The results of this paper are applicable to continuously inhomogeneous materials and, in particular, to functionally graded materials. This revised version was published online in August 2006 with corrections to the Cover Date.     

Analysis of Newton’s Method to Compute Travelling Waves in Discrete Media

We present a variant of Newton’s method for computing travelling wave solutions to scalar bistable lattice differential equations. We prove that the method converges to a solution, obtain existence and uniqueness of solutions to such equations with a small second order term and study the limiting behaviour of such solutions as this second order term tends to zero. The robustness of the algorithm will be discussed using numerical examples. These results will also be used to illustrate phenomena like propagation failure, which are encountered when studying lattice differential equations. We finish by discussing the broad application range of the method and illustrate that higher dimensional systems exhibit richer behaviour than their scalar counterparts.     

Finite dimensional dynamics for evolutionary equations

We suggest a new method for studying finite dimensional dynamics for evolutionary differential equations. We illustrate this method for the case of the KdV equation. As a side result we give constructive solutions of the boundary problem for the Schrodinger equations whose potentials are solutions of stationary KdV equations and their higher generalizations.     

微分求积方法对于桩基大变形分析的应用

本文基于大变形的理论,采用弧坐标首先建立了具有初始位移的桩基的非线性数学模型,一组强非线性的微分-积分方程,其中,地基的抗力采用了Winkeler模型;其次,引入变数变换将微分-积分方程转化为一组非线性微分方程,并用微分求积方法离散了方程组,得到一组离散化的非线性代数方程;最后用Newton-Raphson迭代方法对离散化方程进行了求解,得到了桩基变形前后的构形、弯矩和剪力.计算中选取了两种不同类型的初始位移,并考察了它们对桩基大变形力学行为的影响.